diff --git a/build.py b/build.py
index 8edf636f23..84670ead6d 100755
--- a/build.py
+++ b/build.py
@@ -169,14 +169,19 @@ def step_end():
 vscode_src = os.path.join(qdk_src_dir, "vscode")
 jupyterlab_src = os.path.join(qdk_src_dir, "jupyterlab")
 
+# Qiskit stopped providing binary wheels for Mac on Intel starting with version 2.4.2. Remove this bifurcation when we drop Intel Mac support
+is_intel_mac = platform.system() == "Darwin" and platform.machine() == "x86_64"
+
 QISKIT_VERSION_MATRIX = [
     {
         "label": "qiskit>=1.3.0,<2.0.0",
         "requirements": ["qiskit>=1.3.0,<2.0.0"],
     },
     {
-        "label": "qiskit>=2.0.0,<3.0.0",
-        "requirements": ["qiskit>=2.0.0,<3.0.0"],
+        "label": "qiskit>=2.0.0,<3.0.0" if not is_intel_mac else "qiskit==2.4.1",
+        "requirements": (
+            ["qiskit>=2.0.0,<3.0.0"] if not is_intel_mac else ["qiskit==2.4.1"]
+        ),
     },
 ]
 
diff --git a/source/qdk_package/test_requirements.txt b/source/qdk_package/test_requirements.txt
index dd5d13a093..f3938e2c28 100644
--- a/source/qdk_package/test_requirements.txt
+++ b/source/qdk_package/test_requirements.txt
@@ -1,5 +1,7 @@
 pytest
 expecttest==0.3.0
 pyqir>=0.12.5,<0.13
+# cryptography 49 and later dropped intel mac support. Unfix the version when we drop Intel mac support.
+cryptography==48.0.1; platform_system != 'Windows' or platform_machine == 'AMD64'
 cirq==1.6.1; platform_system != 'Windows' or platform_machine == 'AMD64'
 pandas>=2.1
diff --git a/source/qdk_package/tests-integration/test_requirements.txt b/source/qdk_package/tests-integration/test_requirements.txt
index f7ae43f63a..5c776d0add 100644
--- a/source/qdk_package/tests-integration/test_requirements.txt
+++ b/source/qdk_package/tests-integration/test_requirements.txt
@@ -1,6 +1,11 @@
 pytest==9.0.3
+cryptography==48.0.1
+# cryptography 49 and later dropped intel mac support. Unfix the version when we drop Intel mac support.
 qirrunner==0.9.0
 pyqir>=0.12.5,<0.13
+# Qiskit Aer will pull in Qiskit, and for Intel Mac we want to ensure Qiskit 2.4.1 is used, which is the last version with wheels for that platform.
+# Remove the qiskit requirement when we drop Intel Mac support, as it will be pulled in by qiskit-aer.
+qiskit<=2.4.1; platform_system == "Darwin" and platform_machine == "x86_64"
 qiskit-aer==0.17.2
 qiskit_qasm3_import==0.6.0
 expecttest==0.3.0