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<!DOCTYPE html>
<html lang="es">
<head>
<meta charset="UTF-8" />
<meta name="viewport" content="width=device-width, initial-scale=1.0, maximum-scale=1.0, user-scalable=no, viewport-fit=cover" />
<title>PulseGrowth | Host Cell</title>
<!-- PWA / mobile -->
<!-- PWA theme colors (light + dark) -->
<meta name="theme-color" content="#f2f2f7" media="(prefers-color-scheme: light)" />
<meta name="theme-color" content="#000000" media="(prefers-color-scheme: dark)" />
<!-- iOS PWA -->
<meta name="apple-mobile-web-app-capable" content="yes" />
<meta name="apple-mobile-web-app-status-bar-style" content="black-translucent" />
<meta name="apple-mobile-web-app-title" content="PulseGrowth" />
<!-- Android PWA -->
<meta name="mobile-web-app-capable" content="yes" />
<link rel="manifest" href="./manifest.json" />
<link rel="icon" type="image/png" href="./icon-192.png" />
<link rel="apple-touch-icon" href="./icon-192.png" />
<link rel="stylesheet" href="./src/css/app.css" />
</head>
<body>
<!-- NAV -->
<header class="nav" aria-label="PulseGrowth navigation">
<!-- Row 1: Brand + Host Cell -->
<div class="nav-row nav-row-brand">
<div class="brand">
<img src="./icon-192.png" alt="PulseGrowth" class="app-icon" />
<div class="brand-text">
<h1 class="app-title">PulseGrowth</h1>
<div class="app-subtitle">Two sampling points, full kinetic picture</div>
</div>
</div>
<a class="hc-suite-pill" href="https://www.hostcell.app" target="_blank" rel="noopener noreferrer" aria-label="Host Cell Lab Suite">
<span class="hc-suite-label">Host Cell</span>
</a>
</div>
<!-- Row 2: Tools -->
<div class="nav-row nav-row-tools">
<div class="seg" aria-label="Language selector">
<button id="lang-es" type="button" aria-selected="true">ES</button>
<button id="lang-en" type="button" aria-selected="false">EN</button>
</div>
<button class="btn-info-badge" id="btn-info" type="button" aria-label="Info">!</button>
<button class="btn btn-danger" id="btn-clear-all" type="button" aria-label="Clear all">
<svg class="icon" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" aria-hidden="true">
<path d="M3 6h18M8 6V4h8v2M7 6l1 15h8l1-15"/>
</svg>
</button>
<button class="btn btn-install" id="install-btn" type="button" hidden aria-label="Install app">
<svg class="icon" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" aria-hidden="true">
<path d="M12 3v10M8 11l4 4 4-4M4 20h16"/>
</svg>
<span data-i18n="btnInstall">Instalar</span>
</button>
</div>
</header>
<div class="container">
<!-- iOS install banner -->
<div class="ios-install-banner" id="ios-install-banner" role="note">
<svg width="18" height="18" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" aria-hidden="true">
<path d="M12 3v10M8 11l4 4 4-4M4 20h16"/>
</svg>
<span data-i18n="ios_install_hint">Para instalar: toca <strong>Compartir</strong> → <strong>Añadir al inicio</strong></span>
<button class="btn btn-ghost" id="btn-ios-dismiss" type="button" style="margin-left:auto;padding:4px 10px;font-size:0.80rem;" aria-label="Cerrar">✕</button>
</div>
<!-- Module tiles -->
<div class="tiles" aria-label="Modules overview">
<button class="tile active" type="button" data-go="kin" aria-label="Bio-Kinetics">
<div class="tile-badge mono">01</div>
<div style="min-width:0;">
<p class="tile-title" data-i18n="tile_kin">Bio-Kinetics</p>
<p class="tile-sub" data-i18n="tile_kin_sub">μ · duplicación · IVCD</p>
</div>
</button>
<button class="tile" type="button" data-go="met" aria-label="Metabolics">
<div class="tile-badge mono">02</div>
<div style="min-width:0;">
<p class="tile-title" data-i18n="tile_met">Metabolics (q)</p>
<p class="tile-sub" data-i18n="tile_met_sub">qGlc · qGln</p>
</div>
</button>
<button class="tile" type="button" data-go="feed" aria-label="Feed Control">
<div class="tile-badge mono">03</div>
<div style="min-width:0;">
<p class="tile-title" data-i18n="tile_feed">Feed Control</p>
<p class="tile-sub" data-i18n="tile_feed_sub">plan de corrección</p>
</div>
</button>
</div>
<main>
<!-- PANEL: Kinetics -->
<section class="panel active" id="panel-kin" role="region" aria-label="Bio-Kinetics">
<div class="card" id="card-kinetics">
<div class="card-header">
<div>
<h2 class="card-h" data-i18n="k_title">01. Bio-Kinetics</h2>
<p class="card-desc" data-i18n="k_hint">Growth metrics (μ, doubling time, expansion factor, IVCD)</p>
</div>
<div class="card-right">
<span class="pill mono">μ</span>
</div>
</div>
<div class="form">
<div class="field-group">
<label for="dt-hours" data-i18n="k_dt">Δt <span class="unit">(elapsed time)</span></label>
<div class="grid-2" style="grid-template-columns: 1fr 140px;">
<input type="number" id="dt-hours" step="any" min="0" placeholder="96" data-i18n-placeholder="ph_dt" />
<select id="dt-unit">
<option value="h" selected>h</option>
<option value="d">day</option>
</select>
</div>
</div>
<div class="field-group">
<label data-i18n="k_x">Cell densities <span class="unit">(×10⁶ cell/mL)</span></label>
<div class="grid-2">
<div class="field-group">
<label for="x0" class="unit" data-i18n="k_x0">X0 (initial)</label>
<input type="number" id="x0" step="any" min="0" placeholder="0.2" data-i18n-placeholder="ph_x0" />
</div>
<div class="field-group">
<label for="x1" class="unit" data-i18n="k_x1">X1 (final)</label>
<input type="number" id="x1" step="any" min="0" placeholder="3.0" data-i18n-placeholder="ph_x1" />
</div>
</div>
</div>
<button class="btn btn-primary btn-block" id="btn-kinetics" type="button" data-i18n="k_btn">Analyze kinetics</button>
<div class="result" id="res-kin" aria-live="polite">
<div class="result-head">
<p class="result-title" data-i18n="res_title">Results</p>
<span class="pill" id="kin-status-pill" hidden>—</span>
</div>
<ul class="result-list">
<li class="row">
<div class="k" data-i18n="k_mu">μ (specific growth rate)</div>
<div class="v mono" id="out-mu">---</div>
</li>
<li class="row">
<div class="k" data-i18n="k_td">Doubling time (t<sub>d</sub>)</div>
<div class="v mono" id="out-td">---</div>
</li>
<li class="row">
<div class="k" data-i18n="k_exp">Expansion factor (X1 / X0)</div>
<div class="v mono" id="out-exp">---</div>
</li>
<li class="row">
<div class="k" data-i18n="k_ivcd">IVCD <span class="unit">(10⁶ cell·h/mL)</span></div>
<div class="v mono" id="out-ivcd">---</div>
</li>
</ul>
<details>
<summary data-i18n="details">Details & assumptions</summary>
<div class="meta" id="kin-meta"></div>
</details>
</div>
</div>
</div>
</section>
<!-- PANEL: Metabolics -->
<section class="panel" id="panel-met" role="region" aria-label="Metabolics">
<div class="card" id="card-metabolics">
<div class="card-header">
<div>
<h2 class="card-h" data-i18n="m_title">Metabolics (q)</h2>
<p class="card-desc" data-i18n="m_hint">qGlc / qGln normalized by IVCD · consistent output</p>
</div>
<div class="card-right">
<span class="pill mono">q</span>
</div>
</div>
<div class="form">
<div class="chip-row" aria-label="Metabolics selection" role="group">
<button class="chip" type="button" id="chip-qglc" aria-pressed="true" data-i18n="m_calc_glc">Calcular Glc</button>
<button class="chip" type="button" id="chip-qgln" aria-pressed="true" data-i18n="m_calc_gln">Calcular Gln</button>
</div>
<div class="field-group">
<label data-i18n="m_glc">Glucose, Glc <span class="unit">(C0 → C1)</span></label>
<div class="grid-3">
<input type="number" id="glc0" step="any" placeholder="C0" data-i18n-placeholder="ph_c0" />
<input type="number" id="glc1m" step="any" placeholder="C1" data-i18n-placeholder="ph_c1" />
<select id="u-glc">
<option value="gl" selected>g/L</option>
<option value="mm">mM</option>
</select>
</div>
<div class="hint" data-i18n="m_hint2">Tip: you can compute q for Glc, Gln, or both.</div>
</div>
<div class="field-group">
<label data-i18n="m_gln">Glutamine, Gln <span class="unit">(C0 → C1)</span></label>
<div class="grid-3">
<input type="number" id="gln0" step="any" placeholder="C0" data-i18n-placeholder="ph_c0" />
<input type="number" id="gln1m" step="any" placeholder="C1" data-i18n-placeholder="ph_c1" />
<select id="u-gln">
<option value="gl">g/L</option>
<option value="mm" selected>mM</option>
</select>
</div>
</div>
<button class="btn btn-primary btn-block" id="btn-metabolics" type="button" data-i18n="m_btn">Calculate q</button>
<div class="result" id="res-met" aria-live="polite">
<div class="result-head">
<p class="result-title" data-i18n="res_title">Results</p>
<span class="pill mono" id="met-status-pill" hidden>—</span>
</div>
<ul class="result-list">
<li class="row">
<div class="k">qGlc <span class="unit">(pmol/cell/day)</span></div>
<div class="v mono" id="out-qglc">---</div>
</li>
<li class="row">
<div class="k">qGlc <span class="unit">(pg/cell/day)</span></div>
<div class="v mono" id="out-qglc-pg">---</div>
</li>
<li class="row">
<div class="k">qGln <span class="unit">(pmol/cell/day)</span></div>
<div class="v mono" id="out-qgln">---</div>
</li>
<li class="row">
<div class="k">qGln <span class="unit">(pg/cell/day)</span></div>
<div class="v mono" id="out-qgln-pg">---</div>
</li>
</ul>
<details>
<summary data-i18n="details">Details & assumptions</summary>
<div class="meta" id="met-meta"></div>
</details>
</div>
</div>
</div>
</section>
<!-- PANEL: Feed -->
<section class="panel" id="panel-feed" role="region" aria-label="Feed Control">
<div class="card" id="card-feed">
<div class="card-header">
<div>
<h2 class="card-h" data-i18n="f_title">Feed Control</h2>
<p class="card-desc" data-i18n="f_hint">Simple correction plan to reach target Glc / Gln</p>
</div>
<div class="card-right">
<button class="btn btn-secondary" id="btn-feed-sync" type="button" data-i18n="f_sync">Use C1 from Metabolics</button>
</div>
</div>
<div class="form">
<div class="chip-row" aria-label="Feed selection" role="group">
<button class="chip" type="button" id="chip-feed-glc" aria-pressed="true" data-i18n="f_calc_glc">Calcular Glc</button>
<button class="chip" type="button" id="chip-feed-gln" aria-pressed="true" data-i18n="f_calc_gln">Calcular Gln</button>
</div>
<div class="field-group">
<label data-i18n="f_curr">Current concentrations</label>
<div class="grid-2">
<div class="field-group">
<label for="cur-glc" data-i18n="f_curr_glc">Current Glc</label>
<div class="input-with-select">
<input type="number" id="cur-glc" step="any" min="0" placeholder="e.g. 2.5" data-i18n-placeholder="ph_cur_glc" />
<select id="u-cur-glc" aria-label="Current Glc unit">
<option value="gL" selected>g/L</option>
<option value="mM">mM</option>
</select>
</div>
</div>
<div class="field-group">
<label for="cur-gln" data-i18n="f_curr_gln">Current Gln</label>
<div class="input-with-select">
<input type="number" id="cur-gln" step="any" min="0" placeholder="e.g. 1.8" data-i18n-placeholder="ph_cur_gln" />
<select id="u-cur-gln" aria-label="Current Gln unit">
<option value="mM" selected>mM</option>
<option value="gL">g/L</option>
</select>
</div>
</div>
</div>
<div class="hint" data-i18n="f_curr_hint">You can enter current values directly, or pull them from C1 above.</div>
</div>
<div class="field-group">
<label data-i18n="f_stocks">Stock solutions</label>
<div class="grid-2">
<div class="field-group">
<label for="s-glc" data-i18n="f_sglc">Glc stock</label>
<div class="input-with-select">
<input type="number" id="s-glc" step="any" min="0" placeholder="200" data-i18n-placeholder="ph_stock_glc" />
<select id="u-s-glc" aria-label="Glc stock unit">
<option value="gL" selected>g/L</option>
<option value="gml">g/mL</option>
<option value="mgml">mg/mL</option>
<option value="pct">% w/v</option>
<option value="mM">mM</option>
<option value="M">M</option>
</select>
</div>
</div>
<div class="field-group">
<label for="s-gln" data-i18n="f_sgln">Gln stock</label>
<div class="input-with-select">
<input type="number" id="s-gln" step="any" min="0" placeholder="200" data-i18n-placeholder="ph_stock_gln" />
<select id="u-s-gln" aria-label="Gln stock unit">
<option value="mM" selected>mM</option>
<option value="M">M</option>
<option value="gL">g/L</option>
<option value="gml">g/mL</option>
<option value="mgml">mg/mL</option>
<option value="pct">% w/v</option>
</select>
</div>
</div>
</div>
</div>
<div class="field-group">
<label data-i18n="f_targets">Culture + targets</label>
<div class="grid-2">
<div class="field-group">
<label for="v-cult" data-i18n="f_v">Culture volume <span class="unit">(mL)</span></label>
<input type="number" id="v-cult" step="any" min="0" placeholder="30" data-i18n-placeholder="ph_v" />
</div>
<div class="field-group">
<label for="t-glc" data-i18n="f_tglc">Target Glc <span class="unit">(g/L)</span></label>
<input type="number" id="t-glc" step="any" min="0" placeholder="5" data-i18n-placeholder="ph_tglc" />
</div>
</div>
<div class="grid-2">
<div class="field-group">
<label for="t-gln" data-i18n="f_tgln">Target Gln <span class="unit">(mM)</span></label>
<input type="number" id="t-gln" step="any" min="0" placeholder="4" data-i18n-placeholder="ph_tgln" />
</div>
<div class="field-group">
<label for="feed-safety" data-i18n="f_mode">Mode</label>
<select id="feed-safety">
<option value="exact" data-i18n="f_exact">Exact</option>
<option value="floor" data-i18n="f_floor">Non-negative</option>
</select>
</div>
</div>
<div class="actions-row">
<button class="btn btn-primary btn-block" id="btn-feed" type="button" data-i18n="f_btn">Calculate feed plan</button>
<button class="btn btn-secondary" id="btn-feed-defaults" type="button" data-i18n="f_defaults">Defaults</button>
</div>
</div>
<div class="result" id="res-feed" aria-live="polite">
<div class="result-head">
<p class="result-title" data-i18n="res_title">Results</p>
<span class="pill mono" id="feed-status-pill" hidden>—</span>
</div>
<ul class="result-list">
<li class="row">
<div class="k" data-i18n="f_out_glc">Glucose feed <span class="unit">(mL)</span></div>
<div class="v mono" id="out-fglc">---</div>
</li>
<li class="row">
<div class="k" data-i18n="f_out_gln">Glutamine feed <span class="unit">(mL)</span></div>
<div class="v mono" id="out-fgln">---</div>
</li>
</ul>
<details>
<summary data-i18n="details">Details & assumptions</summary>
<div class="meta" id="feed-meta"></div>
</details>
</div>
</div>
</div>
</section>
</main>
<footer class="hc-footer">
<div class="hc-footer-inner">
<div class="hc-footer-suite">
<span class="hc-footer-name">Host Cell Lab Suite</span>
<span class="hc-footer-slogan">Practical tools for high-performance biotechnology</span>
</div>
<span class="hc-footer-author">© Emiliano Balderas Ramírez</span>
<a href="https://github.com/ebalderasr/PulseGrowth" target="_blank" rel="noopener noreferrer" class="hc-footer-github">
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<div class="sheet" role="document">
<div class="sheet-header">
<h3 class="sheet-title" id="sheet-title" data-i18n="info_title">Scientific fundamentals & warnings</h3>
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<div class="section">
<h4 data-i18n="sci_title">Scientific fundamentals</h4>
<p data-i18n="sci_p1">PulseGrowth uses an exponential growth model between two sampling points to estimate μ and doubling time.</p>
<div class="formula mono">X = X₀ · e^(μ · t)</div>
<div class="formula mono">μ = ln(X₁ / X₀) / Δt</div>
<div class="formula mono">t<sub>d</sub> = ln(2) / μ</div>
<p style="margin-top:10px;" data-i18n="sci_p2">For metabolite-specific rates, IVCD is estimated assuming exponential behavior within the interval.</p>
<div class="formula mono">IVCD = ((X₁ − X₀) / ln(X₁ / X₀)) · Δt</div>
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<h4 data-i18n="q_title">qGlc / qGln logic (unit-consistent)</h4>
<p data-i18n="q_p1">To keep q comparable across inputs, the app converts g/L to mM using MW and reports q in pmol/cell/day.</p>
<div class="formula mono">mM = (g/L ÷ MW) × 1000</div>
<div class="formula mono">q = (ΔC / IVCD) × 24</div>
<p style="margin-top:10px;" data-i18n="q_p2">Sign convention: q > 0 indicates net consumption; q < 0 indicates net accumulation.</p>
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<h4 data-i18n="warn_title">Practical warnings</h4>
<p data-i18n="warn_p1">These calculations assume the culture behaves approximately exponentially between the two sampling points. If μ is low or negative, interpret IVCD and q with caution.</p>
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