diff --git a/backend/pyproject.toml b/backend/pyproject.toml
index bcb3ed29..d99fb305 100644
--- a/backend/pyproject.toml
+++ b/backend/pyproject.toml
@@ -52,7 +52,7 @@ rag = [
 
 [dependency-groups]
 dev = [
-    "ruff==0.15.17",
+    "ruff==0.15.18",
     "mypy==2.1.0",
     "types-jsonschema>=4.25.1.20250822",
     "types-pyyaml>=6.0.12.20260408",  # Type stubs for PyYAML
@@ -60,7 +60,7 @@ dev = [
 ]
 test = [
     "ga4gh-vrs>=2.1.3",
-    "pytest==9.1.0",
+    "pytest==9.1.1",
     "pytest-asyncio>=1.2.0",  # Updated for pytest 8.x compatibility (0.21.1 incompatible)
     "pytest-cov==7.1.0",
     "pytest-xdist>=3.6.0",  # Parallel test execution with per-worker DB isolation
diff --git a/backend/requirements-dev.txt b/backend/requirements-dev.txt
index e4a40b88..770dcd73 100644
--- a/backend/requirements-dev.txt
+++ b/backend/requirements-dev.txt
@@ -5,10 +5,10 @@
 -r requirements.txt
 
 # Development tools (from [dependency-groups.dev])
-ruff==0.15.17
+ruff==0.15.18
 mypy==2.1.0
 
 # Testing (from [dependency-groups.test])
-pytest==9.1.0
+pytest==9.1.1
 pytest-asyncio==1.4.0
 pytest-cov==7.1.0
\ No newline at end of file
diff --git a/backend/requirements.txt b/backend/requirements.txt
index 911062c3..fe4c7b1e 100644
--- a/backend/requirements.txt
+++ b/backend/requirements.txt
@@ -6,7 +6,7 @@ aiohttp==3.14.1
     # via hnf1b-api (pyproject.toml)
 aiosignal==1.4.0
     # via aiohttp
-aiosmtplib==5.1.1
+aiosmtplib==5.1.2
     # via hnf1b-api (pyproject.toml)
 alembic==1.18.4
     # via hnf1b-api (pyproject.toml)
@@ -14,7 +14,7 @@ annotated-doc==0.0.4
     # via fastapi
 annotated-types==0.7.0
     # via pydantic
-anyio==4.13.0
+anyio==4.14.0
     # via
     #   httpx
     #   starlette
@@ -37,7 +37,7 @@ bioutils==0.6.1
     # via ga4gh-vrs
 canonicaljson==2.0.0
     # via ga4gh-vrs
-certifi==2026.5.20
+certifi==2026.6.17
     # via
     #   httpcore
     #   httpx
@@ -54,7 +54,7 @@ dnspython==2.8.0
     # via email-validator
 email-validator==2.3.0
     # via hnf1b-api (pyproject.toml)
-fastapi==0.137.1
+fastapi==0.138.0
     # via hnf1b-api (pyproject.toml)
 fastobo==0.14.1
     # via pronto
@@ -64,7 +64,7 @@ frozenlist==1.8.0
     #   aiosignal
 ga4gh-vrs==2.3.3
     # via hnf1b-api (pyproject.toml)
-greenlet==3.5.1
+greenlet==3.5.2
     # via sqlalchemy
 h11==0.16.0
     # via
@@ -135,9 +135,9 @@ pydantic==2.13.4
     #   fastapi
     #   ga4gh-vrs
     #   pydantic-settings
-pydantic-core==2.46.4
+pydantic-core==2.47.0
     # via pydantic
-pydantic-settings==2.14.1
+pydantic-settings==2.14.2
     # via hnf1b-api (pyproject.toml)
 pyjwt==2.13.0
     # via hnf1b-api (pyproject.toml)
@@ -175,7 +175,7 @@ scipy==1.17.1
     # via hnf1b-api (pyproject.toml)
 six==1.17.0
     # via python-dateutil
-sqlalchemy==2.0.50
+sqlalchemy==2.0.51
     # via
     #   hnf1b-api (pyproject.toml)
     #   alembic